In maturity onset (non-insulin-dependent) obese diabetics and juvenile diabetics in whom diet alone has failed as monotherapy or in combination with insulin, glitazones or sulfonylureas. Also as an adjunct to diet and exercise to improve glycemic control in patients with type-2 diabetes.
Glitazones are used in combination with metformin HCl when glycemic control is poor on metformin HCl monotherapy and maximum tolerated dose (preferable) of metformin HCl has been tried. The combination of glitazone plus metformin HCl is preferred to glitazone plus sulfonylurea, particularly for obese patients.